Pharmaco kinetics and analgesic actions of locally retentive morphine suppository.
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چکیده
منابع مشابه
Synergism between the analgesic actions of morphine and pentazocine.
In a double-blind, placebo-controlled study the analgesic efficacy of the combination of morphine, a mu-opiate receptor agonist and pentazocine, a kappa-opiate receptor partial-agonist was evaluated. Groups of 20 patients received either vehicle, morphine (2, 4, 8 or 16 mg), pentazocine (15, 30 or 60 mg) or a combination of morphine and pentazocine (2 mg or 4 mg and 15 mg or 30 mg, respectively...
متن کاملComparison of Morphine Suppository and Diclofenac Suppository for Pain Management After Elective Caesarean Section.
This study investigated efficacy and side effects of Morphine suppository for pain management after the first elective caesarean delivery in comparison to Diclofenac suppository. One hundred women aged 18-40 with term pregnancies undergoing elective caesarean section for the first time participated in this prospective project. Exclusion criteria included drug sensitivity, fetal malformations or...
متن کاملMorphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial
Background. Renal colic is a medical emergency due to the rapid onset and devastating nature of its pain. Opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are both used as first-line choices in its management. Aim. This study aimed to compare the efficacy and safety of opioids and NSAIDs in the management of acute renal colic. Methods. One hundred and fifty-eight patients were divided ...
متن کاملIntrathecal administration of epinephrine inhibits and reverses analgesic tolerance to analgesic effect of morphine in rats
Introduction: Several researches have reported that stress is able to inhibit the development of morphine tolerance via activating of Hypothalamic-Pituitary-Adrenal (HPA) axis. In the present study we tried to examine the effect of epinephrine, the product of adrenal medulla, on the development of morphine tolerance. Methods: Analgesic tolerance was induced by intrathecal (i.t.) injection of...
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The mechanisms underlying opioid tolerance are not fully understood, but appear to be comprised of two types of plasticity or counter-adaptation, at the cellular level and through neuronal circuits. Current studies mostly emphasize the cellular adaptation mechanisms, which include altered gene expression and receptor desensitization due to phosphorylation and endocytosis. However, the mechanism...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1994
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.25.89